The Red Wings (14-12) tied a season high by committing four errors. Rochester managed just five hits, all singles, with Matt Hague finishing 2-for-4.
The IronPigs (17-13) struck early and often against Wings starter Aaron Slegers (2-3). Slegers, pitching for the first time in nine days, allowed two runs in the 1st and single runs in the 2nd, 3rd and 4th and Lehigh Valley led 5-0.
Slegers surrendered the five runs on seven hits, including a solo home run to Ty Kelly, and a walk with two strikeouts.
IronPigs starter Tom Eshelman made his Triple-A debut and yielded just four hits and a walk with six strikeouts over eight innings while throwing 64 of 87 pitches for strikes.
Alan Busenitz (5th) and Nik Turley (8th) both fired scoreless frames with a pair of strikeouts for the Red Wings. Jason Wheeler made his first regular season relief appearance for Rochester, allowing a run in the 6th and three unearned runs in the 7th.
Rochester never got a runner to third base and only had two runners on base in two innings: the 2nd and 3rd. Twelve Wings hitters were set down in order after a one-out walk to Daniel Palka in the 4th.
NEXT UP: RHP Kyle Gibson makes his season debut with the Red Wings in game two of the series on Tuesday at 7:05 p.m.
NEXT HOME GAME: Monday, May 15 vs. Lehigh Valley (Phillies), 7:05 p.m.